Human contamination by environmental chemicals and type 1 diabetes: Is there any link between the two?

I came across this latest article by Howard SG, Lee DH. J Epidemiol Community Health. 2011 Apr 17. [Epub ahead of print] trying to find the link between human contamination by environmental chemicals and type 1 diabetes mellitus. This was prompted by the unexplained increase in incidence of type 1 diabetes (T1D) in children around the world.
Several literatures have shown links between environmental chemicals in the pathophysiology of type 2 diabetes mellitus, autoimmune diseases etc, the possibility that environmental chemicals eg the endocrine disruptors could promote autoimmune disorders thus predisposing individuals to the development of type 1 diabetes mellitus.
The Abstract reads as follows: “The increasing incidence of type 1 diabetes (T1D) in children around the world is unexplained. Even though various environmental chemicals have been linked to the development of type 2 diabetes as well as other autoimmune diseases, the possibility that environmental chemicals may contribute to the development of T1D has not been adequately evaluated. There is preliminary epidemiological evidence that exposure to certain chemicals, such as N-nitroso compounds, air pollutants and persistent organic pollutants is associated with T1D. Environmental chemicals that can act as endocrine disruptors may affect the development and function of the immune system in ways that could promote autoimmunity, and thereby contribute to the development of T1D. As such, the potential low-dose effects of chemicals should be considered in both epidemiological and experimental study designs of T1D. If chemicals indeed contribute to the development of T1D, then this disease may be partly preventable.”
It is hoped that this would help encourage more researchers to contribute on this important topic.

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2 thoughts on “Human contamination by environmental chemicals and type 1 diabetes: Is there any link between the two?

  1. It is very timely……I, for long, have this believe that EDC plays an important role in the pathogenesis of type 1 DM.

  2. Jalal, this is indeed a very nice abstract worth reading the full article. As ibrahim rightly said, I also have this belief that environmental chemicals must have a role in the causation of DM but only that no final study on that until now. Kudos!

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