A new study on Bisphenol A and Diabetes!

There is no doubt that the introduction of BPA in our packages have greatly transformed the food industry…..thanks to globalisation.
It is my believe that this transformation has come but with a ‘price tag’ attached to it…………..the increase in the number of type 2 diabetes across the globe within the past 10 years may not be unconnected to the increase use of BPA.
I came across this latest study (ahead of print) on BPA and diabetes (refer to my earlier blog post on BPA and Endocrine disruptors), [J Clin Endocrinol Metab. 2011 Sep 28. Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus. Shankar A, Teppala S.] using NHANES.
This latest study looked at 2003-2008, and has the highest OR while the previous studies on BPA and diabetes have looked at years 2003-4 (positive association; OR 1.39) and 2005-6 (no association) and pooled 2003-6 (positive association; OR 1.24).
The Abstract reads as follows:
Background: Bisphenol A (BPA) is a widely used chemical in the manufacture of polycarbonate plastics and epoxy resins. Recent animal studies have suggested that BPA exposure may have a role in the development of weight gain, insulin resistance, pancreatic endocrine dysfunction, thyroid hormone disruption, and several other mechanisms involved in the development of diabetes. However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus.
Methods: We examined the association between urinary BPA levels and diabetes mellitus in the National Health and Nutritional Examination Survey (NHANES) 2003-2008. Urinary BPA levels were examined in quartiles. The main outcome of interest was diabetes mellitus defined according the latest American Diabetes Association guidelines.
Results: Overall, we observed a positive association between increasing levels of urinary BPA and diabetes mellitus, independent of confounding factors such as age, gender, race/ethnicity, body mass index, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of diabetes associated with quartile 4 was 1.50 (1.05-2.14) (p-trend = 0.03). The association was present among normal-weight as well as overweight and obese subjects.
Conclusions: Urinary BPA levels are found to be associated with diabetes mellitus independent of traditional diabetes risk factors. Future prospective studies are needed to confirm or disprove this finding.

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